Cholestatic jaundice caused by D-penicillamine.
نویسندگان
چکیده
D-penicillamine is not generally considered to cause hepatic damage. Cholestatic jaundice developed in a patient with rheumatoid arthritis 4 weeks after penicillamine was added to his regimen, and he died in acute renal failure. The probability that penicillamine caused the cholestasis is discussed.
منابع مشابه
Cholestasis due to D-penicillamine toxicity.
A patient with sero-positive rheumatoid arthritis was treated with D-penicillamine (cumulative dose 3 . 7 3 9 . Three weeks after starting therapy she developed a fever, rash and a cholestatic jaundice. Cessation of D-penicillamine resulted in improvement. However, reintroduction of D-penicillamine 1 0 days later (cumulative dose 2g), was followed by acute hepatic failure and death. Liver biops...
متن کاملStudy of plasma and red cell phospholipid fatty acids in extrahepatic cholestatic jaundice.
The poor outcome in patients with extrahepatic cholestatic jaundice seems in some way related to reticuloendothelial dysfunction. Similar dysfunction can be caused by abnormal tissue phospholipid fatty acid patterns. Little is, however, known about such patterns in extrahepatic cholestatic jaundice. The phospholipid fatty acid patterns in 42 controls were compared with 42 patients with extrahep...
متن کاملGuideline for the Evaluation of Cholestatic Jaundice in Infants: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
For the primary care provider, cholestatic jaundice in infancy, defined as jaundice caused by an elevated conjugated bilirubin, is an uncommon but potentially serious problem that indicates hepatobiliary dysfunction. Early detection of cholestatic jaundice by the primary care physician and timely, accurate diagnosis by the pediatric gastroenterologist are important for successful treatment and ...
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A 65 year old woman with rheumatoid arthritis developed marrow aplasia and jaundice owing to D-penicillamine treatment. Recovery of bone marrow was ineffective, and the patient finally died despite intensive therapeutic measures. The rare coexistence of myelotoxicity and hepatotoxicity is presented and discussed.
متن کاملGuideline for the Evaluation of Cholestatic Jaundice in Infants: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
For the primary care provider, cholestatic jaundice in infancy, defined as jaundice caused by an elevated conjugated bilirubin, is an uncommon but potentially serious problem that indicates hepatobiliary dysfunction. Early detection of cholestatic jaundice by the primary care physician and timely, accurate diagnosis by the pediatric gastroenterologist are important for successful treatment and ...
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عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 37 1 شماره
صفحات -
تاریخ انتشار 1978